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The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) provides a comprehensive framework for diagnosing Autism Spectrum Disorder (ASD). ASD is a neurodevelopmental condition characterized by persistent deficits in social communication and interaction, along with restricted and repetitive patterns of behavior, interests, or activities. The DSM-5 offers diagnostic criteria, including the severity levels of the disorder, and includes guidance on recognizing the variability of symptoms across individuals. This manual facilitates the standardized identification of ASD, ensuring consistency in clinical practice and research. The criteria are intended to aid in early detection, intervention, and understanding of the spectrum’s diverse presentations.